Medway Council announced the passing of James, following a short illness, earlier this week.
One of the top local government public health experts, James was in particular recognised as a leading light in Kent and Medway’s response to COVID-19.
Dr Ghosh, KCC’s Director of Public Health, said: "It is with profound shock and sadness that we are all coming to terms with the passing of James Williams.
“James was a towering leader, an incredible Director of Public Health, a beloved colleague and a dear friend to me. This is such a terrible loss to Medway Council and the Kent and Medway Public Health system of which he was such an integral and important part.
“I will always remember him for his larger-than-life presence, his humour, and above all his humanity and kindness.
“My thoughts are prayers are with his family and I send my deepest condolences to them at this incredibly sad time.”
As well as leading the drive for better health in Medway, James was a major player in addressing health inequalities across the south east. He also played a key role in work to transform the health and care systems in Kent and Medway.
Cedi Frederick, Chair of the Kent and Medway Integrated Care Board, said: "James was a charismatic individual who brought an infectious passion and drive to any project he was a part of.
"His work with the Integrated Care Board and wider system was central in improving the health and care outcomes of the people of Medway.
"I’ve had the pleasure of working closely with James on many occasions - his knowledge, ability to challenge and be challenged made him a fantastic leader who was able to deliver real change and success through his work.
"I, and all my colleagues across the health and care system in Kent and Medway, would like to offer our condolences to James’ family, our thoughts are with you during this time. James will be missed by all.”